Patriots 2008 Draft
2008
| Round/Pick | Pos. | Player | Games/Starts | Notes |
| 1/10 | LB | Jerod Mayo | 16/16 | Mayo became the Patriots starting MLB last year and ended up winning AFC Defensive Rookie of the Year honors.  He had 130 total tackles, along with 1 forced fumble and 1 recovered fumble. In Game No. 10 against the Jets, Mayo took part in 20 tackles. He forced a fumble in Game No. 15 against Arizona. |
| 2/62 | CB | Terrence Wheatley | 6/1 | Wheatley saw very little playing time in the Patriots defense, picking up just two tackles in his six games. His only start came in early November at LCB against Indianapolis. He was not credited with any special teams tackles. |
| 3/78 | LB | Shawn Crable | 0 | Crable went on the injured reserve list on Nov. 5 because of a shin injury. He was inactive for the first eight games of the season. |
| 3/94 | QB | Kevin O’Connell | 2/0 | O’Connell had late appearances in two victories for the Patriots, hitting four of six passes for 23 yards against Miami and Arizona. |
| 4/129 | CB | Jonathan Wilhite | 16/4 | Wihite started the last four games of the season at left CB. Before that he contributed four tackles on special teams. He finished with 19 tackles and 1 interception. He had seven tackles against St. Louis in the seventh game and his interception came against Oakland in the 14th game. |
| 5/153 | WR | Matthew Slater | 14/0 | Slater worked on special teams, returning 11 kickoffs for 155 yards, a 14.1-yard average. He had 12 tackles in coverage. |
| 6/197 | LB | Bo Ruud | 0 | Ruud spent the entire season on the injured-reserve list with an ankle injury suffered in the pre-season. |
